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Scientific Sources & References

Lab-Tested Nutrients

L-Arginine

Mirmiran, P., Bahadoran, Z., Ghasemi, A., & Azizi, F. (2016). The Association of Dietary l-Arginine Intake and Serum Nitric Oxide Metabolites in Adults: A Population-Based Study. Nutrients, 8(5), 311. https://doi.org/10.3390/nu8050311
Bahadoran Z, Mirmiran P, Jeddi S, Carlström M, Azizi F, Ghasemi A. Circulating markers of nitric oxide homeostasis and cardiometabolic diseases: insights from population-based studies. Free Radic Res. 2019 Apr;53(4):359-376. doi: 10.1080/10715762.2019.1587168. Epub 2019 Apr 23. PMID: 30821533.

Taurine

Taurine is gaining significant attention for its wide range of health benefits, particularly in the areas of metabolic and cardiovascular wellness. Clinical trials have demonstrated that taurine supplementation can effectively reduce oxidative stress and inflammatory biomarkers in individuals with type 2 diabetes — key factors involved in the progression of chronic disease. In patients with heart failure, taurine has also been shown to improve overall heart function, enhance myocardial oxygen consumption, and support healthier electrical activity of the heart.
Beyond its cardiovascular impact, emerging scientific research now points to a deeper role for taurine in longevity. Recent studies suggest that taurine deficiency may actually drive aspects of the aging process, making it a potential target for promoting healthy aging and extending lifespan. With its natural presence in foods and strong safety profile, taurine stands out as a powerful and versatile nutrient for long-term health support.

Vitamin C

Ayinde OC, Ogunnowo S, Ogedegbe RA. Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats. BMC Pharmacol Toxicol. 2012 Dec 14;13:17. doi: 10.1186/2050-6511-13-17. PMID: 23241495; PMCID: PMC3554483.
Buettner GR. The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. Arch Biochem Biophys. 1993 Feb 1;300(2):535-43. doi: 10.1006/abbi.1993.1074. PMID: 8434935.
Jackson TS, Xu A, Vita JA, Keaney JF Jr. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res. 1998 Nov 2;83(9):916-22. doi: 10.1161/01.res.83.9.916. PMID: 9797340.
Huang A, Vita JA, Venema RC, Keaney JF Jr. Ascorbic acid enhances endothelial nitric-oxide synthase activity by increasing intracellular tetrahydrobiopterin. J Biol Chem. 2000 Jun 9;275(23):17399-406. doi: 10.1074/jbc.M002248200. PMID: 10749876.

Lab-Tested Nutrients

Beet Root

Clements WT, Lee SR, Bloomer RJ. Nitrate ingestion: a review of the health and physical performance effects. Nutrients. 2014 Nov 18;6(11):5224-64. doi: 10.3390/nu6115224. PMID: 25412154; PMCID: PMC4245587.
Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension. 2015 Feb;65(2):320-7. doi: 10.1161/HYPERTENSIONAHA.114.04675. Epub 2014 Nov 24. PMID: 25421976; PMCID: PMC4288952.
Hobbs DA, Goulding MG, Nguyen A, Malaver T, Walker CF, George TW, Methven L, Lovegrove JA. Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial. J Nutr. 2013 Sep;143(9):1399-405. doi: 10.3945/jn.113.175778. Epub 2013 Jul 24. PMID: 23884387.

Pomegranate

Schini-Kerth VB, Auger C, Kim JH, Etienne-Selloum N, Chataigneau T. Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pflugers Arch. 2010 May;459(6):853-62. doi: 10.1007/s00424-010-0806-4. Epub 2010 Mar 12. PMID: 20224869.
Charles AL, Meyer A, Dal-Ros S, Auger C, Keller N, Ramamoorthy TG, Zoll J, Metzger D, Schini-Kerth V, Geny B. Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production. Exp Physiol. 2013 Feb;98(2):536-45. doi: 10.1113/expphysiol.2012.067496. Epub 2012 Aug 17. PMID: 22903980.

Oak MH, Auger C, Belcastro E, Park SH, Lee HH, Schini-Kerth VB. Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium. Free Radic Biol Med. 2018 Jul;122:161-170. doi: 10.1016/j.freeradbiomed.2018.03.018. Epub 2018 Mar 13. PMID: 29548794.

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Pomegranate

Schini-Kerth VB, Auger C, Kim JH, Etienne-Selloum N, Chataigneau T. Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pflugers Arch. 2010 May;459(6):853-62. doi: 10.1007/s00424-010-0806-4. Epub 2010 Mar 12. PMID: 20224869.
Charles AL, Meyer A, Dal-Ros S, Auger C, Keller N, Ramamoorthy TG, Zoll J, Metzger D, Schini-Kerth V, Geny B. Polyphenols prevent ageing-related impairment in skeletal muscle mitochondrial function through decreased reactive oxygen species production. Exp Physiol. 2013 Feb;98(2):536-45. doi: 10.1113/expphysiol.2012.067496. Epub 2012 Aug 17. PMID: 22903980.

Oak MH, Auger C, Belcastro E, Park SH, Lee HH, Schini-Kerth VB. Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium. Free Radic Biol Med. 2018 Jul;122:161-170. doi: 10.1016/j.freeradbiomed.2018.03.018. Epub 2018 Mar 13. PMID: 29548794.